Degree

PhD in Biophysics and Genetics

University of Colorado Health Sciences Center

BA in Environmental, Population, Organismic, Biology

University of Colorado

Published Works

• Schmidt , L., Taiyab, A., Senkus Melvin, V., Jones, L. K., Williams, T. (2018). Increased Fgf8 Signaling Shifts Cell Fate from Osteogenic to Chondrogenic in the Developing Skull. Disease Models & Mechanisms, 11(6). https://doi.org/10.1242/dmm.031526..
• Melvin, S. V., Feng, W., Hernandez-Lagunas, L., Artinger, B. K., Williams, T. (2013). A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis. . Developmental Dynamics, 24217-831. https://doi.org/10.1002/dvdy.23969.
• Johnson, J. C., Hernandez-Lagunas, L., Feng, W., Melvin, S. V., Williams, T., Artinger, B. K. (2011). Vgll2a is required for neural crest cell survival during zebrafish craniofacial development. . Developmental Biology, 35769-281. https://doi.org/10.1016/j.ydbio.2011.06.034..
• Forni, E. P., Taylor-Burds, C., Melvin, S. V., Williams, T., Wray, S. (2011). Neural crest and ectodermal cells intermix in the nasal placode to give rise to GnRH-1 neurons, sensory neurons, and olfactory ensheathing cells.. Journal of Neuroscience, 18915-6927. https://doi.org/10.1523/JNEUROSCI.6087-10.2011.
• Reid, S. B., Yang, H., Melvin, S. V., Taketo, M., Williams, T. (2010). Ectodermal Wnt/beta-catenin signaling shapes the mouse face.. Developmental Biology, 34961-269. https://doi.org/ 10.1016/j.ydbio.2010.11.012.
• Melvin, S. V., Harrell, C., Adelman, S. J., Kraus, L. W., Churchill, M., Edwards, P. D. (2004). The role of the C-terminal extension (CTE) of the estrogen receptor α and β DNA binding domain in DNA binding and interaction with HMGB.. Journal of Biological Chemistry, 2794763-14771. https://doi.org/10.1074/jbc.M313335200 .
• Melvin, S. V., Roemer, C. S., Churchill, M., Edwards, P. D. (2002). The carboxyl-terminal extension (CTE) of the nuclear hormone receptor DNA binding domain determines interactions and functional response to the HMGB-1/-2 coregulatory proteins.. The Journal of Biological Chemistry, 2775115-25124. https://doi.org/10.1074/jbc.M110400200 .
• Schultz, R. J., Edwards, P. D., Loven, A. M., Melvin, S. V., Nardulli, M. A. (2001). Differential modulation of DNA conformation by estrogen receptors alpha and beta. . Journal of Biological Chemistry, 277702-8707. http://www.jbc.org/content/277/10/8702.long.
• Melvin, S. V., Edwards, P. D. (2001). Expression and purification of recombinant human progesterone receptor in baculovirus and bacterial systems.. (). Humana Press.
• Melvin, S. V., Edwards, P. D. (1999). Coregulatory proteins in steroid hormone receptor action: The role of chromatin high mobility group proteins, HMG-1 and -2.. Steroids, 6476-586. https://www.sciencedirect.com/science/article/pii/S0039128X99000367?via%3Dihub.
• Boonyaratanakornkit, V., Melvin, V., Prendergast, P., Altmann, M., Ronfani, L., Bianchi, E. M., Taraseviciene, L., Nordeen, K. S., Allegretto, A. E., Edwards, P. D. (1998). High-Mobility Group Chromatin Proteins 1 and 2 Functionally Interact with Steroid Hormone Receptors To Enhance Their DNA Binding In Vitro and Transcriptional Activity in Mammalian Cells. Molecular and Cellular Biology, 18(8), 4471-4487. https://doi.org/10.1128/mcb.18.8.4471.

Research Interests

My lab applies genetics and cell biology to study developmental processes. Students can learn molecular biology techniques, including nucleic acid purification, PCR (RT-PCR and qPCR), cloning, in situ hybridization, genetic modification and microinjection.

Office Hours

Tuesday - [10:00 to 11:30]

Wednesday - [9:00 to 11:00]

Thursday - [10:00 to 11:30]